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On the other hand, a similar concentration of WIN although not other CB1R agonists, boosts intracellular Ca2+ focus through Gq/11 protein in transfected HEK-293 cells and cultured hippocampal neurons with endogenous receptor expression [ninety three]. Moreover, in mice hippocampal slices, CB1R expressed in astrocytes is coupled to Gq/11, increases

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